Key result
High serum vitamin D linked to ~55% lower fatal cancer risk in coronary angiography patients.
Why the study?
Epidemiologic studies on vitamin D's protective role against cancer are inconclusive, and prospective data on serum 25-hydroxyvitamin D levels and total cancer mortality are scarce.
Does higher serum 25-hydroxyvitamin D reduce the risk of fatal cancer in patients referred to coronary angiography?
Population
3,299 patients referred to coronary angiography in the Ludwigshafen Risk and Cardiovascular Health study
Comparison
Higher serum 25(OH)D levels (fourth quartile) vs lower levels (first quartile)
Design
Prospective cohort study
Follow-up
Median 7.75 years
Authors
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Does not support changing practice; leaves open whether higher vitamin D levels reduce fatal cancer risk.
Cohort (n=3,299)
Does higher serum 25-hydroxyvitamin D reduce the risk of fatal cancer in patients referred to coronary angiography?
Hazard Ratio: 0.45 (95% CI 0.22–0.93)
Higher serum levels of 25-hydroxyvitamin D are associated with a significantly reduced risk of fatal cancer in patients referred for coronary angiography.
Pilz et al. (2008) conducted a cohort in patients referred to coronary angiography (n=3,299). Serum 25-hydroxyvitamin D [25(OH)D] levels vs. First quartile of 25(OH)D was evaluated on fatal cancer (HR 0.45, 95% CI 0.22-0.93). High serum 25-hydroxyvitamin D levels (fourth vs first quartile) were associated with a lower risk of fatal cancer in patients referred to coronary angiography (HR 0.45; 95% CI 0.22-0.93).
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