Key result
Abstract reports no results on CMR late gadolinium enhancement for predicting major VA and SCD.
Why the study?
A variant-specific risk model for major ventricular arrhythmias in PLN p.(Arg14del)-positive individuals was developed without incorporating CMR late gadolinium enhancement due to limited data availability.
Does CMR late gadolinium enhancement predict major ventricular arrhythmias and sudden cardiac death in Phospholamban p.(Arg14del)-positive individuals?
Observational
Does CMR late gadolinium enhancement predict major ventricular arrhythmias and sudden cardiac death in Phospholamban p.(Arg14del)-positive individuals?
The study aims to evaluate the prognostic value of CMR late gadolinium enhancement for major ventricular arrhythmias and sudden cardiac death in PLN p.(Arg14del)-positive individuals.
No results reported on LGE in PLN p.(Arg14del) carriers; leaves open whether CMR LGE predicts ventricular arrhythmias or SCD.
Phospholamban (PLN) p.(Arg14del)-positive individuals are at increased risk for major ventricular arrhythmias (VA) and sudden cardiac death (SCD). Implantable cardioverter-defibrillator (ICD) implantation remains the gold standard for SCD prevention, and to guide primary prevention decisions, a variant-specific risk model for major VA was developed in 2021.1,2 Although this model demonstrated strong predictive value, delayed gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) could not be incorporated due to limited CMR data availability at the time.
No takes yet. Share an insight, caveat, or question.
Heide et al. (2026) conducted an observational in Phospholamban p.(Arg14del)-positive individuals at risk for major ventricular arrhythmias and sudden cardiac death. CMR Late Gadolinium Enhancement (LGE) was evaluated on Major ventricular arrhythmias (VA) and sudden cardiac death (SCD). The abstract provides background information on the prognostic value of CMR late gadolinium enhancement in Phospholamban p.(Arg14del)-positive individuals but reports no results.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: