The effect of several anti-inflammatory agents given per os, intraperitoneally, or topically to alleviate acute radiodermatitis in guinea pig skin following 3,000 or 4,000 rep β-irradiation was studied. Up to the 21st day post-irradiation, there was pronounced suppression of the acute inflammatory response observed with chloroquine diphosphate, or meclofenamic acid (Cl-583). Chloroquine diphosphate given systemically was most potent among the single drugs tested. Qualitatively, combinations of the drugs given per os were somewhat more effective in suppression of the second erythema and late skin reactions. Topical application of 50% DMSO or of anti-inflammatory drugs dissolved in this solvent resulted in increased inflammatory reactions. Triamcinolone acetonide appeared to be the only active compound when applied topically. The effective anti-inflammatory agents decreased the frequency but did not prevent the onset of ulcers. Ulceration was delayed by about 10 days in the drug-treated animals (as compared with its appearance by the 20th day in controls) and the ulcerated area was smaller and healed more rapidly.
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Chung et al. (2009) studied this question.
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