Additional Data on Hepatic Function Tests in Cystic Fibrosis

Feigelson, J., Pecau, Y., Cathelineau, L. and Navarro, J. (49, Bd Bessieres 75‐Paris XVIIO, France). Additional data on hepatic function tests in cystic fibrosis. Acta Paediatr Scand 64:337, 1975.–Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were observed regularly for a period of 3 years and various liver function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin and prothrombin were assayed. In 9 patients with cirrhosis, the tests were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, one clearly cholestatic and the other of a more cellular type. The distinction was made on the basis of the IgA: Transferrin ratio and of gamma‐glutamyl‐transpeptidase levels. In the non‐cirrhotic patients, a temporary increase of cytolysis and cholestasis was observed in 50 % of the cases.