Ibuprofen and Aseptic Meningitis

Letters and Corrections1 May 1986Ibuprofen and Aseptic MeningitisDANIEL L. BOULAND, M.D., N. LENNARD SPECHT, M.D., DOUGLAS R. HEGSTAD, M.D.DANIEL L. BOULAND, M.D.Search for more papers by this author, N. LENNARD SPECHT, M.D.Search for more papers by this author, DOUGLAS R. HEGSTAD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-731_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Several cases of ibuprofen-induced aseptic meningitis have recently been reported. All but two (1, 2) have occurred in patients with an associated collagen vascular disease. We recently treated a patient without systemic rheumatic disease who had recurring episodes of aseptic meningitis associated with ibuprofen use.A 70-year-old woman was prescribed ibuprofen for osteoarthritis. She presented on three occasions to her physician with altered mental status and meningeal signs necessitating hospitalization. Cerebrospinal fluid studies showed elevated levels of leukocytes and protein, a depressed glucose level, and repeatedly negative cultures. A computed tomographic scan of her head was normal....References1. LAWSONGRADY JM. Ibuprofen-induced aseptic meningitis in a previously healthy patient. West J Med. 1985;143:386-7. MedlineGoogle Scholar2. PERERASEIFFERTGREELEY DAH. Ibuprofen and meningoencephalitis [Letter]. Ann Intern Med. 1984;100:619. LinkGoogle Scholar3. VON REGN C. Recurrent aseptic meningitis due to sulindac. Ann Intern Med. 1983;99:343-4. LinkGoogle Scholar4. RUPPERTBARTH GW. Tolmetin-induced aseptic meningitis. JAMA. 1981;245:67-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL L. BOULAND, M.D.; N. LENNARD SPECHT, M.D.; DOUGLAS R. HEGSTAD, M.D.Affiliations: Riverside General Hospital/University Medical Center Riverside, CA 92503 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCentral adverse drug reactions of NSAIDsDrug-induced meningitis: A review of the literature and comparison with an historical cohort of viral meningitis casesCharacteristics of Meningitis Caused by IbuprofenIbuprofen-Associated Aseptic MeningitisDrug-induced aseptic meningitisRecurrent Ibuprofen-Induced Aseptic MeningitisNonsteroidal Anti-inflammatory Drugs in the Treatment of PericarditisDrug-Induced Aseptic MeningitisDrug- and Chemical-Induced Aseptic Meningitis: A Review of the LiteratureThe Acute Aseptic Meningitis SyndromeÉtat de mal comitial généralisé après prise d'ibuprofène (Brufen®), révélateur d'un lupus érythémateux disséminéThe Aseptic Meningitis SyndromeNoninfectious Causes of Acute CNS InflammationResident Article: Ibuprofen-Associated Meningitisin a Woman with Only Serologic Evidence of a Rheumatologic DisorderDrug-related recurrent meningitisAseptic Meningitis Associated with Naproxen 1 May 1986Volume 104, Issue 5Page: 731-731KeywordsCerebrospinal fluidComputed axial tomographyGlucoseHospitalizationsIbuprofenInterstitial lung diseasesMeningitisOsteoarthritisProteinsSystemic diseases ePublished: 1 December 2008 Issue Published: 1 May 1986 PDF downloadLoading ...