Key result
Lysyl ASA inhibits adrenaline-induced platelet aggregation more effectively than indobufen or combination therapy in dogs.
Why the study?
The differential inhibitory effects of acetylsalicylic acid and indobufen on adrenaline-induced platelet aggregation and kinetics in vivo were not fully characterized.
Does ASA, indobufen, or their combination inhibit adrenaline-induced platelet aggregation and kinetics in anaesthetized dogs?
Does ASA, indobufen, or their combination inhibit adrenaline-induced platelet aggregation and kinetics in anaesthetized dogs?
In a canine model, ASA provided greater inhibition of adrenaline-induced platelet aggregation and mobilization than indobufen or their combination.
Answers are grounded in this paper and cite their sources.
No change to human antiplatelet practice; leaves open whether lysyl ASA outperforms indobufen in clinical settings.
The inhibitory effect of 50 mg/kg lysyl acetylsalicylic acid (ASA) intravenously injected 24 and 4 h before 80 micrograms/kg adrenaline, 40 mg/kg indobufen injected 15 min before, or a combination of ASA plus indobufen on the platelet aggregation and kinetics was evaluated in anaesthetized dogs previously injected with 111indium- (111In-) labelled platelets using gamma-camera dynamics studies. The highest degree of inhibition, indicated by the lowest platelet aggregation ratio decrease and the most significant 111In-labelled platelet mobilization from hepatic and splenic stores with a corresponding increase of labelled and unlabelled platelet counts in blood, was obtained in ASA-treated dogs. Such changes were less marked when ASA plus indobufen was injected. In indobufen-treated dogs a similar mobilization of 111In-labelled platelets with an increase in circulating platelet numbers was evident only after the second adrenaline injection. It is concluded that platelet mobilization is mainly dependent on the production of an ASA-sensitive substance.
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Fortunato et al. (1991) studied this question. Lysyl acetylsalicylic acid (ASA), indobufen, or combination was evaluated on Platelet aggregation and kinetics (platelet aggregation ratio decrease and 111In-labelled platelet mobilization). Lysyl acetylsalicylic acid (ASA) produced the highest degree of inhibition of adrenaline-induced platelet aggregation and the most significant platelet mobilization compared to indobufen or their combination in dogs.
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