Key result
High fasting and postprandial glucose link to increased vascular complications, including retinopathy and higher baPWV.
Why the study?
The relationship between fasting and 2-hour postprandial plasma glucose concentrations and vascular complications in type 2 diabetes was investigated due to unclear associations.
Do elevated fasting and 2-hour postprandial plasma glucose levels correlate with vascular complications in patients with type 2 diabetes mellitus?
Observational (n=206)
Do elevated fasting and 2-hour postprandial plasma glucose levels correlate with vascular complications in patients with type 2 diabetes mellitus?
Elevated fasting and postprandial plasma glucose levels are associated with increased risk of microvascular and macrovascular complications in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Should not yet change T2DM glucose targets; leaves open prospective validation of postprandial links to complications.
OBJECTIVE: To investigate the relationship between fasting and 2-h postprandial plasma glucose concentrations and vascular complications in type 2 diabetes. METHODS: Consecutive patients with type 2 diabetes admitted for blood glucose control were grouped according to their fasting and 2-h postprandial plasma glucose levels. Frequency and severity of diabetic retinopathy and nephropathy, number of carotid artery plaques, coefficient of variation of R-R intervals (CVRR), brachial-ankle pulse wave velocity (baPWV), intima-media thickness, brain natriuretic peptide level, ankle-brachial index, and high-sensitivity C-reactive protein levels were compared. RESULTS: In the 206 patients studied, mean±SD age, glycosylated haemoglobin and duration of diabetes were 63.4±13.7 years, 9.8±1.8% and 13.4±8.9 years, respectively. Patients with high fasting plasma glucose levels had a higher frequency of proliferative retinopathy than those with low fasting levels. Patients with medium or high 2-h postprandial plasma glucose levels had higher baPWV and lower CVRR, respectively, than those with low 2-h levels. There was an inverse correlation between baPWV and CVRR. CONCLUSION: Elevated fasting and postprandial plasma glucose levels are risk factors for vascular complications in type 2 diabetes mellitus.
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Masami Tanaka (2012) conducted an observational in Type 2 diabetes mellitus (n=206). High fasting and 2-hour postprandial plasma glucose levels vs. Low fasting and 2-hour postprandial plasma glucose levels was evaluated on Vascular complications (diabetic retinopathy, nephropathy, carotid artery plaques, CVRR, baPWV, IMT, BNP, ABI, hs-CRP). High fasting and 2-hour postprandial plasma glucose levels were associated with increased vascular complications, including a higher frequency of proliferative retinopathy and higher baPWV.
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