What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Essential Hypertension (n=584). Intervention: 1-hour post-load plasma glucose ≥155 mg/dl vs. 1-hour post-load plasma glucose <155 mg/dl. Primary outcome: Pulse wave velocity (PWV) (p=<0.0001).

September 13, 2012PLoS ONEOpen Access

Association between One-Hour Post-Load Plasma Glucose Levels and Vascular Stiffness in Essential Hypertension

Q: What are the key findings of this study?

In newly diagnosed hypertensive patients with normal glucose tolerance, a 1-hour post-load plasma glucose level ≥155 mg/dl was associated with significantly higher pulse wave velocity (8.4 vs 6.7 m/s) compared to levels <155 mg/dl.

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Key result

In newly diagnosed hypertensive patients with normal glucose tolerance, a 1-hour post-load plasma glucose level ≥155 mg/dl was associated with significantly higher pulse wave velocity (8.4 vs 6.7 m/s) compared to levels <155 mg/dl.

Why the study?

Does a 1-hour post-load plasma glucose ≥155 mg/dl correlate with increased vascular stiffness in newly diagnosed hypertensive patients with normal glucose tolerance?

Population

584 newly diagnosed, uncomplicated hypertensive Caucasian outpatients, aged 35-65 years, 322 men and 262…

Comparison

1-hour post-load plasma glucose ≥155 mg/dl… vs Normal glucose tolerance with 1-hour post-load…

Design

Cross-sectional

Authors

ASAngela Sciacqua RMRaffaele Maio SMSofia Miceli

Discussion

Member takes

Overview

May flag higher vascular risk in new hypertensives with normal glucose; hypothesis-generating, needs longitudinal data before practice change.

Study Design

Type

Cross-Sectional (n=584)

Multicenter

Structured PICO

Does a 1-hour post-load plasma glucose ≥155 mg/dl correlate with increased vascular stiffness in newly diagnosed hypertensive patients with normal glucose tolerance?

Population

584 newly diagnosed, never-treated hypertensive Caucasian adults aged 35-65 years who underwent oral glucose tolerance testing and arterial stiffness measurements.

Exposure

1-hour post-load plasma glucose ≥155 mg/dl during a 75 g oral glucose tolerance test (OGTT) in subjects with normal glucose tolerance (NGT≥155)

Comparator

Normal glucose tolerance with 1-hour post-load plasma glucose <155 mg/dl (NGT<155)

Outcome

Vascular stiffness measured by pulse wave velocity (PWV), augmentation pressure (AP), and augmentation index (AI)surrogate

Main Result

Absolute Event Rate: 8.4% vs 6.7%

p-value: p=<0.0001

In newly diagnosed hypertensive patients with normal glucose tolerance, a 1-hour post-load glucose ≥155 mg/dl identifies individuals with increased arterial stiffness and a higher cardiovascular risk profile.

Limitations

Cross-sectional design limits the ability to establish causal relationships.
Study population was restricted to Caucasian subjects, potentially limiting generalizability to other ethnicities.

Cite This Study

Sciacqua et al. (2012) conducted a cross-sectional in Essential Hypertension (n=584). 1-hour post-load plasma glucose ≥155 mg/dl vs. 1-hour post-load plasma glucose <155 mg/dl was evaluated on Pulse wave velocity (PWV) (p=<0.0001). In newly diagnosed hypertensive patients with normal glucose tolerance, a 1-hour post-load plasma glucose level ≥155 mg/dl was associated with significantly higher pulse wave velocity (8.4 vs 6.7 m/s) compared to levels <155 mg/dl.

synapsesocial.com/papers/6a9d5a3d34685bd77029fcf6 https://doi.org/10.1371/journal.pone.0044470

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September 13, 2012PLoS ONEOpen Access

Association between One-Hour Post-Load Plasma Glucose Levels and Vascular Stiffness in Essential Hypertension

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Does a 1-hour post-load plasma glucose ≥155 mg/dl correlate with increased vascular stiffness in newly diagnosed hypertensive patients with normal glucose tolerance?

Population

584 newly diagnosed, uncomplicated hypertensive Caucasian outpatients, aged 35-65 years, 322 men and 262…

Comparison

1-hour post-load plasma glucose ≥155 mg/dl… vs Normal glucose tolerance with 1-hour post-load…

Design

Cross-sectional

Authors

ASAngela Sciacqua RMRaffaele Maio SMSofia Miceli

Discussion

Member takes

Overview

May flag higher vascular risk in new hypertensives with normal glucose; hypothesis-generating, needs longitudinal data before practice change.

Study Design

Type

Cross-Sectional (n=584)

Multicenter

Structured PICO

Does a 1-hour post-load plasma glucose ≥155 mg/dl correlate with increased vascular stiffness in newly diagnosed hypertensive patients with normal glucose tolerance?

Population

584 newly diagnosed, never-treated hypertensive Caucasian adults aged 35-65 years who underwent oral glucose tolerance testing and arterial stiffness measurements.

Exposure

1-hour post-load plasma glucose ≥155 mg/dl during a 75 g oral glucose tolerance test (OGTT) in subjects with normal glucose tolerance (NGT≥155)

Comparator

Normal glucose tolerance with 1-hour post-load plasma glucose <155 mg/dl (NGT<155)

Outcome

Vascular stiffness measured by pulse wave velocity (PWV), augmentation pressure (AP), and augmentation index (AI)surrogate

Main Result

Absolute Event Rate: 8.4% vs 6.7%

p-value: p=<0.0001

Limitations

Cross-sectional design limits the ability to establish causal relationships.
Study population was restricted to Caucasian subjects, potentially limiting generalizability to other ethnicities.

Cite This Study

synapsesocial.com/papers/6a9d5a3d34685bd77029fcf6 https://doi.org/10.1371/journal.pone.0044470

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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