Key result
A 1-h postload plasma glucose ≥155 mg/dL was associated with significantly worse diastolic function, including higher left atrium dimensions (P<0.0001) and isovolumetric relaxation time (P=0.037).
Why the study?
Is a 1-h postload plasma glucose ≥155 mg/dL associated with worse left ventricular diastolic function in never-treated hypertensive patients with normal glucose tolerance?
Population
161 never-treated hypertensive white subjects
Comparison
1-h postload plasma glucose ≥155 mg/dL during an… vs 1-h postload plasma glucose <155 mg/dL during…
Design
Cross-sectional
Authors
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May flag early diastolic dysfunction in normoglycemic hypertensives; hypothesis-generating, prospective studies needed before clinical adoption.
Cross-Sectional (n=161)
Is a 1-h postload plasma glucose ≥155 mg/dL associated with worse left ventricular diastolic function in never-treated hypertensive patients with normal glucose tolerance?
p-value: p=<0.0001
In never-treated hypertensive patients with normal glucose tolerance, a 1-h postload plasma glucose ≥155 mg/dL is associated with early signs of left ventricular diastolic dysfunction.
Sciacqua et al. (2011) conducted a cross-sectional in Hypertension (n=161). 1-h postload plasma glucose ≥155 mg/dL vs. 1-h postload plasma glucose <155 mg/dL was evaluated on Diastolic function parameters (left atrium dimensions, IVRT, tissue Doppler parameters) (p=<0.0001). A 1-h postload plasma glucose ≥155 mg/dL was associated with significantly worse diastolic function, including higher left atrium dimensions (P<0.0001) and isovolumetric relaxation time (P=0.037).
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