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October 28, 2017Diabetes and Vascular Disease Research

Association between 1-h post-load plasma glucose levels and arterial stiffness in normotensive subjects with normal glucose tolerance

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Key result

Elevated 1-h post-load plasma glucose levels were significantly associated with arterial stiffness in normotensive men with normal glucose tolerance (β = 0.04, p = 0.01).

Why the study?

Is 1-h post-load plasma glucose associated with arterial stiffness in normotensive subjects with normal glucose tolerance?

Population

4,970 normotensive non-industrial workers with normal glucose tolerance, aged 25-55 years. Excluded subjects…

Design

Cross-sectional

Authors

ANAtsushi NakagomiYSYuko SunamiSOSho Okada

Discussion

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Member takes

Overview

May warrant sex-specific caution in normotensives; leaves open causal links and clinical utility pending prospective data.

Study Design

Type

Cross-Sectional (n=4,970)

Structured PICO

Is 1-h post-load plasma glucose associated with arterial stiffness in normotensive subjects with normal glucose tolerance?

P
Population
4,970 normotensive adults aged 25-55 years with normal glucose tolerance undergoing regular health check-ups.
O
Outcome
Arterial stiffness determined by brachial-ankle pulse-wave velocitysurrogate

Main Result

Effect estimate: β = 0.04

p-value: p=0.01

Elevated 1-h post-load plasma glucose levels are associated with increased arterial stiffness in normotensive, middle-aged men with normal glucose tolerance.

Cite This Study

Nakagomi et al. (2017) conducted a cross-sectional in Normotensive with normal glucose tolerance (n=4,970). 1-h post-load plasma glucose was evaluated on Arterial stiffness (brachial-ankle pulse-wave velocity) (β = 0.04, p=0.01). Elevated 1-h post-load plasma glucose levels were significantly associated with arterial stiffness in normotensive men with normal glucose tolerance (β = 0.04, p = 0.01).

synapsesocial.com/papers/6a9cc94f4fe4142e92f7bcabhttps://doi.org/10.1177/1479164117736509
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated 1‐h plasma glucose following 75‐g oral glucose load is a predictor of arterial stiffness in subjects with normal glucose tolerance2012 · 16 citations
  2. 2One-Hour Post-Load Plasma Glucose Levels are Associated with Early Arterial Stiffness in Subjects with Different Glucose Tolerance2022 · 9 citations
  3. 3Grading effect of abnormal glucose status on arterial stiffness and a new threshold of 2‐h post‐load glucose based on a Chinese community study2017 · 4 citations
  4. 4Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes2011 · 127 citations
  5. 5A slightly high-normal glucose level is associated with increased arterial stiffness in Japanese community-dwelling persons with pre-diabetes2013 · 9 citations