Key result
The co-occurrence of diabetes and hypertension was associated with the highest increase in brachial-ankle pulse wave velocity (MD 403.24; 95% CI 372.43-434.05; P<0.001).
Why the study?
The rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels were largely unknown.
Does the combination of high blood pressure and high blood glucose synergistically increase arterial stiffness in a community-based cohort?
Cross-Sectional (n=7,402)
Does the combination of high blood pressure and high blood glucose synergistically increase arterial stiffness in a community-based cohort?
Answers are grounded in this paper and cite their sources.
The co-occurrence of hypertension and diabetes synergistically increases arterial stiffness, highlighting the importance of aggressive management of both conditions to prevent vascular aging.
Background: Increased arterial stiffness measured by brachial-ankle pulse wave velocity is associated with cardiovascular disease. However, the rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels are largely unknown. Methods: This study was based on the baseline data of a Chinese community-based atherosclerosis cohort which included 7402 individuals. Using generalized linear regression models, the relationship between blood glucose levels and brachial-ankle pulse wave velocity, and the relationship between blood pressure levels and brachial-ankle pulse wave velocity were examined. Results: A marked interaction between hypertensive state and diabetic state was seen for brachial-ankle pulse wave velocity ( P for interaction <0.001). The adjusted coefficient for subjects stratified by hypertensive groups and diabetic states showed that the highest brachial-ankle pulse wave velocity risk subjects were those who had both diabetes and hypertension (B=403.24; 95% CI: 372.43–434.05; P <0.001). Conclusions: The participants with increased arterial stiffness demonstrate a high prevalence of higher blood pressure. When high blood glucose levels co-occur with high blood pressure levels, there is a remarkable increase in arterial stiffness.
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Dai et al. (2019) conducted a cross-sectional in Arterial stiffness (n=7,402). Co-occurrence of hypertension and diabetes vs. Absence of hypertension and diabetes was evaluated on Brachial-ankle pulse wave velocity (B 403.24, 95% CI 372.43-434.05, p=<0.001). The co-occurrence of diabetes and hypertension was associated with the highest increase in brachial-ankle pulse wave velocity (MD 403.24; 95% CI 372.43-434.05; P<0.001).
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