Key result
Slightly high-normal fasting plasma glucose was independently associated with increased arterial stiffness compared to the lowest normal glucose group.
Why the study?
Is a slightly high-normal fasting plasma glucose level associated with increased arterial stiffness in non-diabetic community-dwelling persons?
Cross-Sectional (n=322)
No
Is a slightly high-normal fasting plasma glucose level associated with increased arterial stiffness in non-diabetic community-dwelling persons?
Even slightly high-normal fasting glucose levels (95-100 mg/dL) are associated with increased arterial stiffness in non-diabetic individuals, suggesting early vascular changes occur before the onset of overt diabetes.
Answers are grounded in this paper and cite their sources.
May prompt earlier vascular assessment in high-normal glucose; leaves open causal role and need for prospective validation.
Impaired fasting glucose (IFG) in diabetes is a risk factor for arterial stiffness and cardiovascular disease (CVD), but the impact of a slightly high-normal glucose level remains controversial. We investigated whether slightly high-normal fasting plasma glucose (FPG) was independently associated with arterial stiffness in non-diabetic community-dwelling persons. We recruited 114 men aged 69 ± 9 years (range 40-89) and 208 women aged 68 ± 7 years (range 36-84) during their annual health examination in a single community. Arterial stiffness was evaluated by the mean of the right and left brachial-ankle pulse wave velocity (ba-PWV). Age-adjusted ba-PWV increased significantly from the lowest to the highest FPG group (p < 0.001). Multiple linear regression analyses for ba-PWV revealed that FPG levels (β=0.154, p < 0.001) were independently and significantly associated with ba-PWV. The multivariate-adjusted ba-PWV value of the high-normal glucose group (Group 3: 95-100 mg/dL) was significantly higher than that of the lowest normal glucose group (Group 1: 52-89 mg/dL) (p=0.021), and the ba-PWV value in the IFG group (Group 4: 101-125 mg/dL) was significantly higher than those of the normal glucose groups (Group 1: <90 mg/dL; Group 2: 90-94 mg/dL) (p<0.001 and p=0.009, respectively). Slightly high-normal glucose levels were associated with arterial stiffness in Japanese community-dwelling persons.
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Kawamoto et al. (2013) conducted a cross-sectional in Pre-diabetes (n=322). Slightly high-normal fasting plasma glucose vs. Lowest normal glucose group (52-89 mg/dL) was evaluated on Arterial stiffness evaluated by the mean of the right and left brachial-ankle pulse wave velocity (ba-PWV) (β=0.154, p=<0.001). Slightly high-normal fasting plasma glucose was independently associated with increased arterial stiffness compared to the lowest normal glucose group.
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