Key result
Short-term use of multiple antipsychotics linked to neuroleptic malignant syndrome without muscular rigidity.
Why the study?
Neuroleptic malignant syndrome is a potentially lethal reaction to neuroleptics with incompletely understood etiology and variable presentation including muscle rigidity.
Case Report (n=1)
No
Neuroleptic malignant syndrome can present atypically without muscle rigidity following the use of multiple antipsychotics.
Clinicians should consider NMS despite absent rigidity after multiple antipsychotics; this case leaves open questions on atypical presentation frequency.
Neuroleptic malignant syndrome (NMS) is an uncommon but potentially lethal idiosyncratic reaction which may emerge in the aftermath of the treatments with neuroleptics demonstrating itself with the symptoms of altered consciousness, high fever, impaired autonomic functions, and muscle rigidity. Although various risk factors have been identified for NMS, its etiology is not completely known. The mortality and morbidity related with NMS could be reduced by early diagnosis, interruption of the neuroleptics used within a short period and aggressive treatment. Our case is different from general NMS cases due to lack of rigidity. A NMS case which developed within a short time in the aftermath of multiple antipsychotic use and wherein no rigidity was observed shall be discussed in this case report.
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Özdemir et al. (2018) conducted a case report in Neuroleptic Malignant Syndrome (n=1). Multiple antipsychotics was evaluated. A 49-year-old male developed neuroleptic malignant syndrome without the typical symptom of muscular rigidity after receiving multiple antipsychotic medications over a short period.
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