Key result
Elevated plasma MMP-9 is linked to failed arterial recanalization after thrombolysis in acute stroke.
Why the study?
Matrix metalloproteinases may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients.
Are plasma MMP-2 and MMP-9 levels associated with thrombolysis failure in acute stroke patients?
Observational (n=70)
Are plasma MMP-2 and MMP-9 levels associated with thrombolysis failure in acute stroke patients?
Elevated plasma MMP-9 levels may be associated with thrombolysis resistance in acute stroke patients.
May signal thrombolysis resistance; hypothesis-generating and should not yet change practice.
BACKGROUND AND PURPOSE: Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS: Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS: The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS: MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.
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Heo et al. (2003) conducted an observational in Acute stroke (n=70). Thrombolysis failure (non-recanalization) vs. Successful recanalization was evaluated on MMP-9 plasma level. Plasma MMP-9 levels were significantly higher in acute stroke patients whose arteries were not recanalized after thrombolysis compared to those who achieved recanalization.
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