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We read with great interest the systematic review and meta-analysis by Rocha et al. on Intranasal Dexmedetomidine (IN-DEX) for procedural sedation in children.[1]This rigorous synthesis, encompassing 28 randomized controlled trials and more than 1,600 participants, provides a comprehensive quantitative framework for the clinical planning of IN-DEX monotherapy.The finding that doses of 2-3 µg.kg -¹ yield an 84% success rate
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Soares et al. (2026) studied this question.
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