Key result
Rainbow trout MVa highly resembles other vertebrate MVa and expresses exclusively in hypophysis and brain.
Why the study?
The nucleotide sequence for myosin V was explored in a fish species for the first time to understand the organization, evolution, and expression of myosins in early vertebrates.
This study provides the first exploration of the myosin V nucleotide sequence in a fish species, contributing to the understanding of myosin evolution and the rainbow trout genome.
Answers are grounded in this paper and cite their sources.
No immediate clinical translation; extends myosin V phylogeny to teleosts while leaving cardiac roles open.
Partial cDNA sequences of myosin V from rainbow trout Oncorhynchus mykiss were analyzed and showed high similarity to MVa from other vertebrates. Phylogenetic analysis has shown that events resulting in the formation of paralogous copies of myosin Va, Vb, and Vc occurred before the divergence of vertebrates into different classes. Expression analysis of myosin Va, Vb, and Vc in different O. mykiss tissues revealed MVa exclusively expressed in hypophysis and brain whereas Vb and Vc were expressed in practically all tissues analyzed. The nucleotide sequence for myosin V was explored in a fish species for the first time and these results represent an important start in understanding the organization, evolution, and expression of myosins in early vertebrates. The data presented here represent contributions to the knowledge of rainbow trout genome. A better understanding of this economically important species could assist in development of improved strains of this fish for aquaculture.
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Rancura et al. (2008) studied this question. Partial cDNA sequence analysis of myosin V from rainbow trout showed high similarity to MVa from other vertebrates, with MVa exclusively expressed in the hypophysis and brain.
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