Key result
Myosin Va is broadly expressed in diverse neuronal populations across the central nervous system of rainbow trout, indicating phylogenetic maintenance of its main functions.
No immediate clinical implications; confirms myosin Va conservation across vertebrates and leaves human translation open.
This study presents data on myosin Va localization in the central nervous system of rainbow trout. We demonstrate, via immunoblots and immunocytochemistry, the expression of myosin Va in several neuronal populations of forebrain, midbrain, hindbrain and spinal cord. The neuronal populations that express myosin Va in trout constitute a very diverse group that do not seem to have many specific similarities such as neurotransmitters used, cellular size or length of their processes. The intensity of the immunoreactivity and the number of immunoreactive cells differ from region to region. Although there is a broad distribution of myosin Va, it is not present in all neuronal populations. This result is in agreement with a previous report, which indicated that myosin Va is approximately as abundant as conventional myosin II and kinesin, and it is broadly involved in neuronal motility events such as axoplasmatic transport. Furthermore, this distribution pattern is in accordance with what was shown in rats and mice; it indicates phylogenetic maintenance of the myosin Va main functions.
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Rancura et al. (2007) studied Myosin Va localization in rainbow trout central nervous system. Myosin Va was evaluated on Myosin Va localization and expression. Myosin Va is broadly expressed in diverse neuronal populations across the central nervous system of rainbow trout, indicating phylogenetic maintenance of its main functions.
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