Key result
High OPN3 expression is linked to lower survival and promotes lung adenocarcinoma metastasis in vitro.
Why the study?
The expression and role of Opsin3 (OPN3) in lung adenocarcinoma and its impact on metastasis were unclear.
Does OPN3 expression promote metastasis and epithelial-mesenchymal transition in lung adenocarcinoma?
Population
Lung adenocarcinoma tissues and normal lung tissues, HCC827 and A549 cell lines
Comparison
Overexpression or decreased expression of OPN3 vs normal expression
Design
Preclinical laboratory study using western blot, qPCR, immunohistochemistry, and cell migration assays
Authors
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High OPN3 expression was associated with poorer survival and metastasis in LUAD; leaves open its value as a prognostic biomarker pending prospective validation.
Does OPN3 expression promote metastasis and epithelial-mesenchymal transition in lung adenocarcinoma?
OPN3 acts as an oncogene promoting metastasis and epithelial-mesenchymal transition in lung adenocarcinoma.
Xu et al. (2019) studied Lung adenocarcinoma. OPN3 expression vs. Normal lung tissues / low expression was evaluated on Survival rates, cell migration and invasion. High expression of OPN3 in lung adenocarcinoma tissues was associated with lower survival rates and promoted epithelial-mesenchymal transition and metastasis in vitro.
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