Eukaryotic proteins are tagged for degradation by addition of ubiquitin or single amino acids. Now Jentsch discusses a new prokaryotic protein tagging system reported by Keiler et al. ( p. 990 ) in this issue of Science . In this novel tagging pathway, nascent polypeptides, translated from truncated mRNAs lacking stop codons, receive short COOH-terminal peptide tags encoded by a separate RNA, 10Sa RNA.
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Stefan Jentsch (1996) studied this question.
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