How to Create Animal Models Using Genetic Knowledge?

New animal models have emerged in recent years; some are based on the possibility of genetic modifications as close as possible to those found in humans.We chose to show what could be achieved through genetic transcription.We chose 3 models: APP and APPxPS1 transgenic mice, frontotemporal dementia and tau mutations in the microtubule-associated protein tau and α -synuclein accumulation in Lewy body diseases.