Key result
Abdominoperineal resection linked to ~31% higher quality of life scores versus conservative resections.
Why the study?
The quality of life comparison between abdominoperineal resection and conservative resections (LAR and ULAR) in rectal cancer patients was unclear.
Does abdominoperineal resection improve quality of life compared to conservative resections in rectal cancer patients?
Cross-Sectional (n=26)
No
Does abdominoperineal resection improve quality of life compared to conservative resections in rectal cancer patients?
Absolute Event Rate: 73.72% vs 56.22%
p-value: p=0.005
The study reports a statistically significant difference in QoL scores between surgical approaches (p=0.005), although the authors' conclusion states there is no significant difference.
May suggest better QoL after abdominoperineal resection; hypothesis-generating and should not change practice pending higher-level evidence.
Background: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death worldwide with an incidence of 10.2%. The treatment of CRC has changed over the past 25 years. Two surgical procedures are used: abdominoperineal resection (AR) and low anterior resection (LAR) and ultra-low (ULAR). The recurrence rate and quality of life are similar. Objective: To compare quality of life for rectal cancer (CRC) patients treated with abdominoperineal resection vs conservative resections: low anterior (LAR) and ultra-low (ULAR) in UMAE Puebla. Methods: A comparative, observational, cross-sectional study was conducted in CRC patients treated during 2015-2019 in a 3rd level hospital in Puebla. Two groups were formed: those managed with RA, and those managed with LAR/ULAR. The EORT QLQ CR-29 and EuroQol scale was applied. Descriptive statistics and Man-Whitney U were applied for comparisons. Results: A total of 26 patients were recruited: 18with AR and 18 with LAR/ULAR. A mean QoL was recorded in the RAP group of 73.72 (SD 16.92, minimum 31.46, maximum 95.09) and in the RAB/RAUB group of 56.22 (SD 6.29, minimum 47.51, maximum 68.96), with a value of p=0.005. Conclusion: There is no significant difference in the quality of life of patients of CRC patients operated by AR, LAR and ULAR (non-conservative and conservative approach).
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Segura-González et al. (2023) conducted a cross-sectional in Rectal cancer (n=26). Abdominoperineal resection (AR) vs. Conservative resections (LAR and ULAR) was evaluated on Quality of life (p=0.005). Abdominoperineal resection was associated with a mean quality of life score of 73.72 compared to 56.22 for conservative resections (P=0.005).
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