Key result
MT1-MMP expression rises in colon adenoma and cancer but fails to predict node-negative recurrence.
Why the study?
Membrane type 1 matrix metalloproteinase expression in colonic polyps and carcinoma in situ and its association with recurrence of colon cancers had not been defined.
Does membrane type 1 matrix metalloproteinase expression correlate with colon cancer progression or predict recurrence in node-negative colon cancer?
Observational (n=68)
Does membrane type 1 matrix metalloproteinase expression correlate with colon cancer progression or predict recurrence in node-negative colon cancer?
p-value: p=<0.001
MT1-MMP expression increases with colon cancer progression but does not predict recurrence in node-negative disease.
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MT1-MMP tracks invasion but not recurrence risk; leaves open its biomarker utility in node-negative colon cancer.
Malhotra et al. (2002) conducted an observational in Colon cancer (n=68). Membrane type 1 matrix metalloproteinase expression vs. Normal mucosa and nonrecurrent colon cancer was evaluated on Membrane type 1 matrix metalloproteinase expression score (p=<0.001). Membrane type 1 matrix metalloproteinase expression increased from normal mucosa to adenoma (P<0.001) and invasive cancer (P<0.009), but did not predict recurrence in node-negative colon cancer.
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