Key result
Anemia is linked to ~337% greater major bleeding risk in patients on factor Xa inhibitors.
Why the study?
Bleeding complications remain a significant concern despite the better efficacy and safety profiles of DOACs compared to vitamin K antagonists in patients with atrial fibrillation.
What are the clinical risk factors for major bleeding in Korean patients with atrial fibrillation receiving factor Xa inhibitors?
Observational (n=372)
Yes
What are the clinical risk factors for major bleeding in Korean patients with atrial fibrillation receiving factor Xa inhibitors?
Odds Ratio: 4.37 (95% CI 1.81–10.53)
p-value: p=<0.01
Supports anemia screening and diuretic caution before Xa inhibitor initiation in AF; hypothesis-generating and requires prospective validation.
Background : Direct oral anticoagulants (DOACs) are widely used for stroke prevention in patients with non-valvular atrial fibrillation because DOACs have better efficacy and safety profiles than traditional vitamin K antagonists.Despite these advantages, bleeding complications remain a significant concern.This study aimed to comprehensively identify clinical factors associated with major bleeding in Korean patients with atrial fibrillation receiving factor Xa inhibitors. Methods :Patients with atrial fibrillation who received factor Xa inhibitors (apixaban, edoxaban, or rivaroxaban) between June 2018 and December 2021 at
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Lee et al. (2025) conducted an observational in Atrial Fibrillation (n=372). Anemia vs. Absence of anemia was evaluated on Major bleeding as defined by International Society on Thrombosis and Haemostasis criteria (adjusted OR 4.37, 95% CI 1.81-10.53, p=<0.01). Anemia and concomitant diuretic use were identified as significant independent risk factors for major bleeding in patients receiving factor Xa inhibitors, with anemia increasing the risk by over 4-fold (adjusted OR 4.37).
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