Addition of activated T cells or of cells from a cytotoxic T cell clone to mixed leukocyte cultures abolished the generation of cytolytic activity in these cultures. The cytolytic T cell response is completely restored if T cell growth factor (interleukin 2) is added, indicating that the suppression is due to absorption or consumption of IL2 by the added cells.
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Günther et al. (1982) studied this question.
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