Key result
Multimodality therapy with resection of rare right atrial metastasis achieves 6-month clinical stability.
Why the study?
Cardiac metastasis from non-seminomatous germ cell tumors is exceedingly rare and represents an aggressive disease course requiring multidisciplinary management.
Case Report (n=1)
No
Multimodality therapy including aggressive surgical resection can achieve disease control in rare cases of testicular non-seminomatous germ cell tumors with intracardiac metastasis.
May support multimodality therapy in rare cardiac metastases; leaves open generalizability and prospective validation.
Cardiac metastasis from non‐seminomatous germ cell tumors (NSGCTs) is exceedingly rare and represents an aggressive disease course. We report a 37‐year‐old man with a testicular yolk sac tumor who initially declined adjuvant therapy after orchiectomy. He later developed pulmonary metastases treated with BEP chemotherapy, followed by progressive disease with brain involvement requiring emergent decompressive craniectomy and whole‐brain radiotherapy. Salvage TIP chemotherapy was administered. Persistent pulmonary disease led to thoracotomy, during which a discrete metastatic deposit in the right atrium was identified and surgically resected. Histopathology confirmed metastatic yolk sac tumor in all sites. The patient subsequently received maintenance therapy with oxaliplatin and bevacizumab. Follow‐up has been based on clinical assessment and serial tumor marker monitoring, demonstrating ongoing biochemical and clinical stability for approximately 6 months following initiation of maintenance therapy, with the patient remaining on treatment at the time of this report. This case highlights the unpredictable metastatic behavior of NSGCTs and underscores the importance of multidisciplinary management in achieving disease control in rare and life‐threatening metastatic presentations.
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Fazilat‐Panah et al. (2026) conducted a case report in Testicular yolk sac tumor with intracardiac, pulmonary, and brain metastases (n=1). Multimodality therapy (surgery, chemotherapy, radiotherapy, maintenance) was evaluated on Clinical and biochemical stability. Multimodality management including surgical resection of a rare right atrial metastasis, chemotherapy, and radiotherapy achieved clinical and biochemical stability for 6 months.
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