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September 18, 2026World Journal of Surgical OncologyOpen Access

Myxoid liposarcoma exhibits an extrapulmonary-dominant metastatic pattern, with distant metastasis occurring in ~32% of patients.

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Why the study?

Cohort data describing the metastatic pattern and temporal sequence of pulmonary and extrapulmonary metastasis in Korean patients with myxoid liposarcoma were limited.

Population

47 patients with histologically confirmed myxoid liposarcoma undergoing surgical resection at a Korean tertiary sarcoma referral center

Comparison

Pulmonary versus extrapulmonary metastasis timing and pattern

Design

Single-center retrospective cohort study

Follow-up

Median 56.9 months

Key result

Myxoid liposarcoma exhibited an extrapulmonary-dominant metastatic pattern, with distant metastasis occurring in 31.9% of patients and 93.3% of those having extrapulmonary involvement first.

Authors

YLYoungkeun LeeSKSeung Je KimSSSung Wook Seo

Discussion

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Overview

Supports extrapulmonary surveillance emphasis in myxoid liposarcoma; extends prior observations in a Korean surgical cohort.

Key Points

  • To characterize the anatomical distribution and within-patient temporal sequence of pulmonary versus extrapulmonary distant metastasis in patients surgically treated for myxoid liposarcoma.
  • Reviewed 47 patients with histologically confirmed myxoid liposarcoma who underwent surgical resection at a Korean tertiary sarcoma referral center between January 2008 and December 2024.
  • Tracked the incidence and specific dates of first pulmonary and extrapulmonary distant metastasis across a median follow-up of 56.9 months to determine recurrence patterns and survival outcomes.
  • Distant metastasis occurred in 31.9% (15/47) of patients, with 93.3% (14/15) exhibiting extrapulmonary disease at first metastasis; among 7 patients with both forms, extrapulmonary metastasis preceded (n=4) or occurred simultaneously with (n=3) pulmonary disease, while only 1 of 15 developed lung disease first.
  • Local recurrence occurred in 12.8% (6/47) of patients, appearing more frequently in patients referred after outside surgery (4/16) than in those presenting with primary disease (2/31).
  • The 2- and 5-year overall survival rates were 82.0% and 73.5%, the 2- and 5-year distant metastasis-free survival rates were 86.4% and 79.8%, and the median survival from first distant metastasis was 33.7 months.

Study Design

Type

Cohort (n=47)

Multicenter

No

Structured PICO

P
Population
47 patients with histologically confirmed myxoid liposarcoma who underwent surgical resection, followed for a median of 56.9 months.
E
Exposure
Surgical resection (observational cohort)
O
Outcome
Occurrence and anatomical distribution of distant metastasis (DM), within-patient temporal sequence of pulmonary versus extrapulmonary involvement, local recurrence (LR), overall survival (OS), distant metastasis-free survival (DMFS), and post-metastasis survivalhard clinical

In Korean patients with myxoid liposarcoma, distant metastasis is predominantly extrapulmonary and tends to precede or accompany pulmonary disease, supporting the need for extrapulmonary surveillance.

Cite This Study

Lee et al. (2026) conducted a cohort in Myxoid liposarcoma (n=47). Myxoid liposarcoma was evaluated on Distant metastasis. Myxoid liposarcoma exhibited an extrapulmonary-dominant metastatic pattern, with distant metastasis occurring in 31.9% of patients and 93.3% of those having extrapulmonary involvement first.

synapsesocial.com/papers/6aacf5ed0c46fbdff987dd3ahttps://doi.org/10.1186/s12957-026-04570-6
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