Metastatic Soft Tissue Sarcoma With Cardiac Involvement: A Case Study on the Role of Multimodal Imaging in Diagnosis and Management

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Metastatic soft tissue sarcoma with cardiac involvement (n=1). Intervention: Multimodal imaging (Echocardiography, CMR, CT). Primary outcome: Detection and characterization of cardiac metastasis.

Q: What does this research mean for the field?

Multimodal imaging is critical for the accurate diagnosis and clinical management of cardiac metastasis arising from soft-tissue sarcoma. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Azin Alizadehasl; Sina Akhavan; Seyedeh Fatemeh Hosseini Jebelli; Amirafraz fallah najmabadi; Nargeuss Abbaszade Marzbali; Fateme Yousefimoghaddam; Mehrdad Haghazali; Sajjad Rafiei

doi:10.1002/ccr3.72112

September 1, 2026Clinical Case ReportsOpen Access

Metastatic Soft Tissue Sarcoma With Cardiac Involvement: A Case Study on the Role of Multimodal Imaging in Diagnosis and Management

View Full Paper

Ask AI

Bookmark

Share

Key result

Multimodal imaging detects massive left atrial sarcoma metastasis extending from the lung.

n=1

Figures

Why the study?

The diagnosis and management of rare cardiac metastasis from soft-tissue sarcoma require early detection and a multidisciplinary approach, with the role of multimodal imaging being critical.

Key Points

To describe the diagnostic evaluation and multidisciplinary management of rare cardiac metastasis in a patient with soft-tissue sarcoma using multimodal imaging.
Clinical and diagnostic evaluation of a 36-year-old male with a history of soft-tissue sarcoma presenting with progressive shortness of breath and chest pain.
Multimodal imaging assessment utilizing transthoracic echocardiography, transesophageal echocardiography, computed tomography, and cardiac magnetic resonance imaging.
Multidisciplinary tumor board coordination to deliver palliative chemotherapy and targeted radiation therapy.
Transthoracic echocardiography identified a heterogeneous left atrial mass measuring approximately 5 × 3 cm partially obstructing the right pulmonary veins, with a left ventricular ejection fraction of 40%–45%.
Cardiac magnetic resonance imaging characterized a 120 × 95 mm mass extending from the right lung into the left atrium with mild perfusion, alongside a right ventricular ejection fraction of 43%.
Following palliative chemotherapy and targeted radiation therapy, the patient experienced reduced dyspnea and chest pain with stabilized cardiac function.

Study Design

Type

Case Report (n=1)

Structured PICO

P

Population

A 36-year-old male with a history of soft-tissue sarcoma who presented with progressive shortness of breath and chest pain and was diagnosed with a large left atrial metastasis.

I

Intervention

Multimodal imaging (transthoracic echocardiography, cardiac magnetic resonance imaging, and computed tomography) followed by palliative chemotherapy and targeted radiation therapy.

O

Outcome

Diagnosis and characterization of cardiac metastasis, and clinical response to palliative therapy.

Multimodal imaging is essential for the accurate diagnosis and characterization of rare cardiac metastases, enabling timely multidisciplinary management and symptom palliation.

Implication

May aid diagnosis of rare cardiac metastases; leaves open optimal management strategies in sarcoma.

Abstract

This case highlights the critical role of multimodal imaging in diagnosing and managing rare cardiac metastasis from soft‐tissue sarcoma, emphasizing the importance of early detection and a multidisciplinary approach to improve outcomes.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Alizadehasl et al. (2026) conducted a case report in Metastatic soft tissue sarcoma with cardiac involvement (n=1). Multimodal imaging (Echocardiography, CMR, CT) was evaluated on Detection and characterization of cardiac metastasis. Multimodal imaging successfully identified a 120 × 95 mm metastatic mass extending from the right lung into the left atrium in a 36-year-old man with soft-tissue sarcoma.

synapsesocial.com/papers/6aacf5ed0c46fbdff987dd4a https://doi.org/10.1002/ccr3.72112

View Full Paper

Ask AI

Bookmark

Share

Metastatic Soft Tissue Sarcoma With Cardiac Involvement: A Case Study on the Role of Multimodal Imaging in Diagnosis and Management

Figures

Key Points

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Metastatic Soft Tissue Sarcoma With Cardiac Involvement: A Case Study on the Role of Multimodal Imaging in Diagnosis and Management

Figures

Key Points

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading