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The study of 5,7-dihydroxycoumarins as nucleophilic agents in the SNH reaction with pyrimidines showed that the reaction does not stop at the stage of formation of σH-adduct as intermediate in the SNH mechanism but proceeds further with annulation of the 1,3,5-oxadiazocine ring in moderate to excellent yields. The structures of the obtained compounds were confirmed by NMR spectroscopy and X-ray diffraction. A primary in vitro assessment of their antitumor activity was performed.
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Fatykhov et al. (2025) studied this question.
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