Key result
Experimental canine mitral stenosis is linked to decreased pulmonary vascular resistance without altering cardiac index.
Why the study?
The study aimed to characterize cardiac function and pulmonary hemodynamics in experimental mitral stenosis over time.
What are the hemodynamic effects of experimental mitral stenosis in dogs?
What are the hemodynamic effects of experimental mitral stenosis in dogs?
In a canine model of experimental mitral stenosis, elevated pulmonary vein pressure was associated with decreased pulmonary vascular resistance and maintained cardiac index.
Challenges assumptions of fixed pulmonary hypertension in mitral stenosis; leaves open human translation.
The results of 85 combined right and left heart catheterizations in normal dogs and dogs with experimental mitral stenosis are presented. Animals lived as long as 10 months with elevated pulmonary vein pressures. Pulmonary vein pressures in excess of 15 mm. Hg were associated with mitral orifice areas which were smaller than those found in normal animals. Elevation of pulmonary vein pressure was associated with a decrease in the pulmonary vascular pressure gradient, with no change in cardiac index as measured and with a decrease in calculated pulmonary vascular resistance.
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Haddy et al. (1953) studied Experimental mitral stenosis. Experimental mitral stenosis vs. Normal dogs was evaluated on Hemodynamic parameters including pulmonary vein pressure, pulmonary vascular pressure gradient, cardiac index, and pulmonary vascular resistance. Experimental mitral stenosis in dogs with elevated pulmonary vein pressure was associated with decreased pulmonary vascular pressure gradient and resistance, with no change in cardiac index.
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