April 1, 1967Circulation
Exercise Tolerance and Hemodynamic Studies After Replacement of Canine Mitral Valve With and Without Preservation of Chordae Tendineae
Why the study?
Does preservation of chordae tendineae during mitral valve replacement improve cardiac function in a canine model?
Population
17 dogs (15 undergoing mitral valve replacement, 2 subjected to sham operation)
Comparison
Mitral valve replacement with Starr-Edwards… vs Mitral valve replacement with Starr-Edwards…
Design
Preclinical
Follow-up
Up to 2 months
Authors
Discussion
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Member takes
Implication
Chordae preservation confers no functional benefit after mitral replacement in this canine model; leaves open translation to human practice.
Structured PICO
Does preservation of chordae tendineae during mitral valve replacement improve cardiac function in a canine model?
P
Population
17 dogs (15 undergoing mitral valve replacement, 2 subjected to sham operation)
I
Intervention
Mitral valve replacement with Starr-Edwards ball-valve prosthesis with preservation of chordae tendineae
C
Comparator
Mitral valve replacement with Starr-Edwards ball-valve prosthesis with totally or partially resected chordae tendineae, or sham operation
O
Outcome
Cardiac function (cardiac output, left atrial pressure, hemodynamic values at rest and during acetylcholine infusion, exercise tolerance)surrogate
In a canine model, preservation of chordae tendineae during mitral valve replacement with a Starr-Edwards prosthesis did not significantly affect cardiac performance compared to resection.
Cite This Study
Rastelli et al. (1967) studied this question.