Key result
Mitral valve replacement with the Hall-Kaster prosthesis in dogs resulted in 7 of 33 animals surviving 4-6 weeks, with extensive anticoagulation and antibiotics found necessary to prevent fatal thrombosis.
Population
33 dogs undergoing mitral valve replacement
Design
Preclinical
Follow-up
4-6 weeks
Authors
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Highlights thrombosis prevention needs in early canine models; leaves open translation to modern human prostheses.
Extensive anticoagulation and antibiotic therapy are essential for survival and prevention of valve thrombosis in a canine model of mitral valve replacement.
Aasen et al. (2008) studied Mitral valve replacement (n=33). Mitral valve replacement with the Hall-Kaster prosthesis was evaluated on Survival and model viability. Mitral valve replacement with the Hall-Kaster prosthesis in dogs resulted in 7 of 33 animals surviving 4-6 weeks, with extensive anticoagulation and antibiotics found necessary to prevent fatal thrombosis.
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