Key result
Three heparin and warfarin antithrombotic regimes were equally ineffective in preventing valve thrombosis in dogs after mitral disc valve implantation, resulting in 12 thrombosis-related deaths.
Why the study?
Do different heparin and warfarin antithrombotic regimes prevent valve thrombosis in dogs receiving mitral disc valves?
Population
33 Labrador retriever dogs who received Hall-Haster mitral disc valves during extracorporeal circulation…
Comparison
Three antithrombotic regimes using heparin and… vs Comparison between the three antithrombotic…
Design
Preclinical
Follow-up
4 weeks
Authors
Loading...
These regimes failed to prevent valve thrombosis in a canine mitral valve model; leaves open need for intensified prophylaxis in experimental cardiac surgery.
Do different heparin and warfarin antithrombotic regimes prevent valve thrombosis in dogs receiving mitral disc valves?
Standard heparin and warfarin regimens are insufficient to prevent valve thrombosis in a canine model of mitral disc valve implantation, necessitating more intensive prophylaxis for experimental open-heart surgery.
Dale et al. (2008) studied Valve thrombosis post-mitral disc valve implantation (n=33). Heparin and Warfarin antithrombotic regimes vs. Three different regimens compared against each other was evaluated on Valve thrombosis and survival. Three heparin and warfarin antithrombotic regimes were equally ineffective in preventing valve thrombosis in dogs after mitral disc valve implantation, resulting in 12 thrombosis-related deaths.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: