Key result
Severance of the subvalvular apparatus after mitral valve replacement in dogs significantly reduced LV dP/dtmax (-15%), ejection fraction (-16%), and stroke volume (-24%).
Why the study?
Does preservation of the subvalvular apparatus improve left ventricular function compared to severance in an experimental dog model of mitral valve replacement?
Population
8 dogs undergoing mitral valve replacement with St. Jude prostheses
Comparison
Preservation of the subvalvular apparatus vs Severance of the subvalvular apparatus
Design
Preclinical
Authors
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May support chordal preservation in mitral valve replacement; leaves open translation to human outcomes.
Does preservation of the subvalvular apparatus improve left ventricular function compared to severance in an experimental dog model of mitral valve replacement?
In an experimental dog model, preserving the subvalvular apparatus during mitral valve replacement significantly preserves left ventricular systolic function and prevents adverse geometric changes compared to severing the chordae.
Gams et al. (1990) studied Mitral valve replacement (n=8). Severance of the subvalvular apparatus (cutting chordae tendineae) vs. Preservation of the subvalvular apparatus (pre-cut) was evaluated on Left ventricular function parameters (LV dP/dtmax, ejection fraction, stroke volume). Severance of the subvalvular apparatus after mitral valve replacement in dogs significantly reduced LV dP/dtmax (-15%), ejection fraction (-16%), and stroke volume (-24%).
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