Toward a Better Understanding of the Etiology of Left Ventricular Dysfunction after Mitral Valve Replacement: An Experimental Study with Possible Clinical Implications
Why the study?
Does a mitral prosthesis with a flexible annulus improve left ventricular function compared to a rigid prosthesis in an experimental pig model of mitral valve replacement?
Population
Isolated heart preparation in pigs (n=24 total; 14 in Part I, 10 in Part II)
Comparison
Mitral prosthesis with a flexible annulus… vs Standard rigid prosthesis; Baseline before…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Flexible mitral prostheses may better preserve LV function in pig models; leaves open translation to clinical mitral valve replacement.
Structured PICO
Does a mitral prosthesis with a flexible annulus improve left ventricular function compared to a rigid prosthesis in an experimental pig model of mitral valve replacement?
P
Population
Isolated heart preparation in pigs (n=24 total; 14 in Part I, 10 in Part II)
I
Intervention
Mitral prosthesis with a flexible annulus (Part II); Division of chordae tendineae and fixation of mitral annulus (Part I)
C
Comparator
Standard rigid prosthesis (Part II); Baseline before division (Part I)
O
Outcome
Global left ventricular function (systolic pressure, developed pressure, first derivative of LV pressure [dP/dt])surrogate
In an experimental pig model, division of chordae tendineae impairs LV function, and a flexible mitral annulus prosthesis preserves LV function better than a rigid prosthesis.
Cite This Study
Spence et al. (1986) studied this question.