Key result
Extended LMWH for at least five weeks after total hip replacement minimizes DVT.
Why the study?
Post-surgical DVT is often underdiagnosed and subclinical DVT is a major source of pulmonary embolism after total hip replacement surgery, necessitating evaluation of optimal thromboprophylaxis duration.
Does extended thromboprophylaxis with low-molecular-weight heparin for at least 5 weeks prevent deep vein thrombosis and pulmonary embolism in patients undergoing total hip replacement surgery?
Does extended thromboprophylaxis with low-molecular-weight heparin for at least 5 weeks prevent deep vein thrombosis and pulmonary embolism in patients undergoing total hip replacement surgery?
Extended out-of-hospital prophylaxis with low-molecular-weight heparin for at least 5 weeks is recommended to minimize subclinical DVT and pulmonary embolism following total hip replacement surgery.
May support extended LMWH post-hip replacement; leaves open RCT confirmation before practice change.
Post-surgical deep vein thrombosis (DVT) is often underdiagnosed by clinical assessment alone. Subclinical DVT is a major source of pulmonary embolism, which is an important cause of death, particularly following total hip replacement surgery. Results from pathophysiological studies and recently conducted, prospective double-blind venographic studies in Europe and North America suggest that, in patients undergoing total hip replacement surgery, thromboprophylaxis with a low-molecular-weight heparin should be continued for at least 5 weeks post-operatively to minimize this serious complication.
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Ola E. Dahl (2000) conducted a review in Post-surgical deep vein thrombosis (DVT). Thromboprophylaxis with a low-molecular-weight heparin was evaluated on Deep vein thrombosis (DVT) and pulmonary embolism. Thromboprophylaxis with a low-molecular-weight heparin should be continued for at least 5 weeks post-operatively in patients undergoing total hip replacement surgery to minimize DVT.
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