Why the study?
The heart developed metabolic and molecular cardioprotective pathways over millions of years, including recent clinical applications and molecular mechanisms that require synthesis and clarification.
This review summarizes the evolutionary development and clinical application of metabolic and molecular cardioprotective pathways, including the RISK and SAFE paths, against ischaemia-reperfusion injury.
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Lionel H. Opie (2012) conducted a review in Acute coronary syndromes. Cardioprotective strategies (GIK, conditioning, lifestyle) was evaluated.
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