Key result
Echocardiography detects cardiac involvement and predicts prognosis in hypereosinophilic syndrome and EGPA.
Why the study?
Hypereosinophilia-associated syndrome includes rare systemic diseases such as HES and EGPA with unclear cardiac manifestations requiring further characterization.
Case Report (n=2)
Echocardiography is crucial for detecting and differentiating cardiac manifestations in rare hypereosinophilia-associated syndromes like HES and EGPA.
Echocardiography may aid evaluation of hypereosinophilic syndromes; leaves open need for larger prospective confirmation.
Hypereosinophilia-associated syndrome is a rare group of systemic diseases without certain underlying causes. Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome (CSS), are initial considerations, when underlying causes remains unexplained despite of complete evaluation of hypereosinophilia. In this study, we report two rare cases, one case of HES with Loeffler endocarditis, and the other one of EGPA with restrictive cardiomyopathy mimicking myocardial infarction, to further address differential chief cardiac manifestations between HES and EGPA. Key roles of echocardiography played in detection of cardiac involvements, diagnosis, and prognosis prediction are also highlighted.
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Jin et al. (2017) conducted a case report in Hypereosinophilia-associated syndrome (n=2). Echocardiography was evaluated on Cardiac manifestations. Echocardiography plays a key role in detecting cardiac involvements, diagnosing, and predicting prognosis in patients with hypereosinophilic syndrome and eosinophilic granulomatosis with polyangiitis.
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