Key result
Medical therapy and appropriate anticoagulation induced favorable long-term ventricular remodeling in a series of 5 patients with Loeffler endocarditis.
Why the study?
Does medical therapy and anticoagulation induce favorable ventricular remodeling in patients with Loeffler endocarditis?
Case Report (n=5)
Does medical therapy and anticoagulation induce favorable ventricular remodeling in patients with Loeffler endocarditis?
Medical therapy and anticoagulation can induce favorable long-term ventricular remodeling in patients with Loeffler endocarditis.
Should not yet change practice; hypothesis-generating case series warrants prospective validation.
BACKGROUND: Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis. METHODS AND RESULTS: We describe 5 patients, including 3 with long-term echocardiographic follow-up, in whom apical obliteration due to fibro-thrombotic thickening of the endocardium showed favorable patterns of evolution. In one patient there was almost complete resolution of the obliterative process with consequently increased effective ventricular volume. In two patients formation of a flow-passage in the fibrocalcific apical 'floor' between the main medioventricular cavity and the apical chamber, leading to a 'double-chambered' left ventricle was observed. CONCLUSIONS: Medical therapy and appropriate anticoagulation, can induce favorable long-term ventricular remodeling in Loeffler endocarditis.
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Lofiego et al. (2005) conducted a case report in Loeffler endocarditis (n=5). Medical therapy and anticoagulation was evaluated on Ventricular remodeling. Medical therapy and appropriate anticoagulation induced favorable long-term ventricular remodeling in a series of 5 patients with Loeffler endocarditis.
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