Key result
Surgery and chemotherapy fail to prevent three-month mortality in adult prostate embryonal rhabdomyosarcoma.
Why the study?
Primary embryonal rhabdomyosarcoma of the prostate in adults is extremely rare with limited management data mostly derived from pediatric trials.
Case Report (n=1)
Primary embryonal rhabdomyosarcoma of the prostate in adults is extremely rare and carries a poor prognosis despite surgery and chemotherapy.
Documents rapid fatality despite treatment in rare adult prostatic embryonal rhabdomyosarcoma; leaves optimal strategies undefined.
Introduction: Primary embryonal rhabdomyosarcoma of prostate (ERMP) is an extremely rare pathological and clinical entity in adults. It’s characterized by extensive loco-regional spread and a tendency to metastasize by blood stream and regional lymphatics. In adult patients, data available on the management of ERMP are limited and mostly derived from the pediatric clinical trials on rhabdomyosarcoma. Case Report: We report a case of group III ERMP approached by initial surgery followed by the administration of three courses of vincristine, doxorubicin and Cyclophosphamide regimen. The patient succumbed to disease complications three months after the original diagnosis. Conclusion: The most appropriate therapeutic approach for adults with ERMP remains questionable. Further studies are needed to improve the understanding of biological behavior of ERMP in adults and to define the best therapeutic strategy in locally advanced disease.
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Amaadour et al. (2014) conducted a case report in Primary embryonal rhabdomyosarcoma of prostate (ERMP) (n=1). Surgery followed by vincristine, doxorubicin and cyclophosphamide was evaluated on Survival. An adult patient with group III primary embryonal rhabdomyosarcoma of the prostate treated with surgery and chemotherapy died from disease complications three months after diagnosis.
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