Key result
Long non-coding RNAs detect CAD with high diagnostic accuracy and ~100% sensitivity.
Why the study?
Long non-coding RNAs have emerged as promising biomarkers for Coronary Artery Disease, but their diagnostic utility requires systematic evaluation.
Do long non-coding RNAs (lncRNAs) provide accurate diagnostic value as biomarkers for Coronary Artery Disease (CAD)?
Systematic Review (n=5,301)
Do long non-coding RNAs (lncRNAs) provide accurate diagnostic value as biomarkers for Coronary Artery Disease (CAD)?
Long non-coding RNAs demonstrate high sensitivity and specificity, highlighting their potential utility as diagnostic biomarkers for coronary artery disease.
Coronary Artery Disease (CAD) remains a leading global health challenge. Long non-coding RNAs (lncRNAs) have emerged as promising biomarkers for CAD. A systematic review following PRISMA guidelines evaluated 22 studies to assess long non-coding RNAs (lncRNAs) as biomarkers for Coronary Artery Disease (CAD). Among 27 identified lncRNAs in 5,301 participants, KCNQ1OT1, HIF1A-AS2, and APOA1-AS showed notable diagnostic accuracy, with 100% sensitivity and 80% specificity. One lncRNA, OTTHUMT00000387022, exhibited the highest specificity at 98%. Despite methodological differences, consistent diagnostic relevance was observed across studies, with sensitivity and specificity reaching 100% and 98%, respectively. This review underscores the potential of lncRNAs as CAD biomarkers, with 23 upregulated and 4 downregulated lncRNAs identified. Their stable presence in human biofluids and strong association with CAD suggest their utility as diagnostic markers and potential therapeutic targets.
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Veeraraghavan et al. (2025) conducted a systematic review in Coronary Artery Disease (CAD) (n=5,301). Long non-coding RNAs (lncRNAs) was evaluated on Diagnostic accuracy (sensitivity and specificity). Long non-coding RNAs demonstrated high diagnostic accuracy for Coronary Artery Disease, with sensitivity reaching 100% and specificity up to 98%.
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