Key result
Genetic polymorphisms may explain variable efficacy and side effects of cardiovascular antithrombotic therapy.
Why the study?
Inter-individual heterogeneity in response to antithrombotic therapy limits clinical benefits in cardiovascular diseases, and few factors explaining this variability have been identified.
Genetic polymorphisms affecting drug disposition, metabolism, transporters, or targets may explain inter-individual heterogeneity in antithrombotic therapy efficacy and side effects.
Supports genotype-informed antithrombotic selection; leaves open prospective outcome trials before clinical adoption.
Thrombosis is the most important underlying mechanism of coronary heart disease and embolic stroke. Therefore, antithrombotic therapy is commonly used in cardiovascular diseases. Unfortunately, the benefits are limited, and an important proportion of treated patients will suffer a new thrombotic event. Lack of clinical benefits may be related to heterogeneous response to antithrombotic treatment among individuals (inter-individual heterogeneity). Few factors have been identified to be involved in this inter-individual heterogeneity. Recently, pharmacogenetic has emerged as a new field in medicine that tries to identify gene variants able to explain the heterogeneity in patient's response to a drug. Polymorphisms affecting disposition, metabolism, transporters or targets of the drug could modify the individual response to one therapy, and probably its side effects. The present review article explores the genetic influence on antithrombotic drug efficacy, analysing the modulating role of different polymorphisms on individuals' response to drugs commonly used in current day practice.
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Marı́n et al. (2005) conducted a review in Cardiovascular diseases requiring antithrombotic therapy. Genetic polymorphisms was evaluated. Genetic polymorphisms affecting drug disposition, metabolism, transporters, or targets may explain inter-individual heterogeneity in the efficacy and side effects of cardiovascular antithrombotic therapy.
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