Key result
ALP therapy resolves symptoms and normalizes imaging in a case mimicking miliary tuberculosis.
Why the study?
Acute lupus pneumonitis resembling miliary tuberculosis is rare and difficult to diagnose due to similar clinical and imaging features.
Case Report (n=1)
Acute lupus pneumonitis can mimic miliary tuberculosis clinically and radiographically, requiring careful diagnostic workup to ensure appropriate treatment.
ALP mimicking miliary TB in SLE warrants inclusion in differentials; leaves open optimal diagnostic and management strategies.
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems and organs, with pulmonary involvement known to be associated with disease prognosis and mortality. Acute lupus pneumonitis (ALP) resembling miliary tuberculosis (TB) is rare. Here, we present a case of ALP mimicking miliary TB and review the literature. A 19-year-old male student was referred to our hospital with fever. Although the patient met the diagnostic criteria for SLE, diffuse miliary nodules in both lungs were observed on a chest computed tomography scan. A series of tests, including pathological testing of bronchoscopy brushes, T-lymphocyte culture + interferon assay (A + B), tuberculin test, detection of mycobacterium TB DNA, and acid-fast bacilli smear in bronchoalveolar lavage fluid, were unable to confirm the presence of TB infection. We considered the patient to have ALP. After beginning ALP therapy, his symptoms disappeared, and the imaging and hematological results returned to normal. Miliary TB and ALP have similar clinical manifestations and imaging changes, which make diagnosis difficult. This case highlights the need to ensure accurate diagnosis and treatment to improve prognosis.
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Li et al. (2023) conducted a case report in Acute lupus pneumonitis resembling miliary tuberculosis (n=1). Acute lupus pneumonitis (ALP) therapy was evaluated on Symptom resolution and normalization of imaging and hematological results. Acute lupus pneumonitis therapy led to the disappearance of symptoms and normalization of imaging and hematological results in a 19-year-old male with ALP mimicking miliary tuberculosis.
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