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Case report demonstrates pulmonary embolism and deep vein thrombosis following nitrous oxide abuse, suggesting elevated homocysteine may mediate thrombotic risk.
BACKGROUND: O, pulmonary embolism (PE), and deep vein thrombosis (DVT) and emphasizes the role of homocysteine (Hcy) in thrombotic events. CASE SUMMARY: O abuse sought evaluation after acute chest pain. A diagnostic workup revealed PE, DVT, and hyperhomocysteinemia. The patient was successfully treated with thrombolytic and anticoagulant therapy. Moreover, his Hcy level decreased and returned to normal after Hcy-lowering therapy. CONCLUSION: O abuse might increase the risk of PE and DVT, although there have been few studies previously.
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Sun et al. (2019) studied this question.
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