Key result
Canine hyperthyroidism increases cardiac microsomal calcium accumulation and exchange without altering mitochondrial morphology or ATPase.
Why the study?
The influence of hyperthyroidism on calcium uptake and binding by cardiac microsomal fractions and mitochondrial structure was investigated to understand its cardiac effects.
Population
Heart muscle microsomes from hyperthyroid and euthyroid dogs
Comparison
Hyperthyroid state vs euthyroid state
Design
Preclinical experimental study
Authors
Loading...
May inform mechanisms of thyroid effects on cardiac calcium handling; leaves open translation to human disease.
Hyperthyroidism in dogs enhances calcium accumulation and exchange in cardiac microsomes without altering mitochondrial structure or energy stores.
Nayler et al. (1971) studied Hyperthyroidism. Hyperthyroidism vs. Euthyroid state was evaluated on Calcium accumulation and exchange by cardiac microsomes. Hyperthyroidism in dogs increased calcium accumulation and exchange by cardiac microsomes compared to euthyroid dogs, without altering mitochondrial morphology or ATPase activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: