Population
Single rat cardiac myocytes (hypothyroid, euthyroid, and hyperthyroid models)
Comparison
Varying thyroid status, isoprenaline, and… vs Euthyroid state and baseline conditions
Design
Preclinical
Authors
Loading...
Hypothesis-generating for thyroid effects on cardiac calcium handling; leaves open relevance to human disease.
Increasing thyroid hormone levels elevate resting and contracting cytosolic calcium in cardiomyocytes, while reducing the relative impact of calcium-entry interventions like beta-agonists.
Beekman et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: