July 1, 1997Cardiovascular ResearchOpen Access

Thyroid hormones increase the contractility but suppress the effects of β-adrenergic agonist by decreasing phospholamban expression in rat atria

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Population

Rat atria from rats with induced hypothyroidism or hyperthyroidism, and euthyroid controls

Comparison

Induction of hypothyroidism or hyperthyroidism vs Euthyroid rats

Design

Preclinical

Follow-up

1 to 6 weeks

Authors

AKAllen KaasikUniversity of Tartu

Discussion

Member takes

Implication

Should not alter clinical management; leaves open whether phospholamban effects translate to human arrhythmias or HF.

Structured PICO

Population

Rat atria from rats with induced hypothyroidism or hyperthyroidism, and euthyroid controls

Intervention

Induction of hypothyroidism (0.05% 6-n-propyl-2-thiouracil in drinking water for 6 weeks) or hyperthyroidism (daily subcutaneous injections of L-thyroxine 1 microgram/g body weight for 1 week)

Comparator

Euthyroid rats

Outcome

Contractile performance, SR Ca2+-uptake, and phospholamban/SR Ca2+-pump protein expressionsurrogate

Thyroid hormones increase baseline atrial contractility but blunt the inotropic response to beta-adrenergic stimulation by decreasing the phospholamban/SR Ca2+-pump ratio.

Cite This Study

Allen Kaasik (1997) studied this question.

synapsesocial.com/papers/6a6f98aaf44fa9f079dd0e62 https://doi.org/10.1016/s0008-6363(97)00069-2

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Thyroid hormones increase the contractility but suppress the effects of β-adrenergic agonist by decreasing phospholamban expression in rat atria

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thyroid hormones increase the contractility but suppress the effects of β-adrenergic agonist by decreasing phospholamban expression in rat atria

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider