Population
Phospholamban-deficient mice and their isogenic wild types
Comparison
Induction of hypothyroidism and hyperthyroidism vs Euthyroid state and wild-type mice
Design
Preclinical
Authors
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Findings in phospholamban-deficient mice warrant clinical caution; extends mechanistic understanding of thyroid effects on contractility but remains hypothesis-generating.
Alterations in phospholamban level or activity are critical determinants of the contractile responses to altered thyroid states in the mammalian heart.
Kiss et al. (1998) studied this question.
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