Key result
In a rat model of hypothyroidism, T3 treatment restored left ventricular ejection fraction and dose-dependently increased phospholamban phosphorylation.
Why the study?
Does T3 treatment improve LV contractile function and alter PLB phosphorylation in a rat model of hypothyroidism?
Population
Rat model of hypothyroidism
Comparison
T3 treatment (2.5 and 7.0 microg/day) vs Hypothyroid rats without T3 treatment
Design
Preclinical
Authors
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T3 may enhance LV function via PLB in hypothyroid rats; leaves open human translation and should not change practice.
Does T3 treatment improve LV contractile function and alter PLB phosphorylation in a rat model of hypothyroidism?
p-value: p=< 0.05
Thyroid hormone (T3) enhances left ventricular contractile function in hypothyroid rats by regulating both the expression and phosphorylation of cardiac phospholamban.
Ojamaa et al. (2000) studied Hypothyroidism. T3 (Thyroid hormone) vs. Hypothyroid control was evaluated on Left ventricular contractile function (ejection fraction) and phospholamban phosphorylation (p=< 0.05). In a rat model of hypothyroidism, T3 treatment restored left ventricular ejection fraction and dose-dependently increased phospholamban phosphorylation.
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