Why the study?
Does thyroid hormone alter left ventricular performance and the expression of contractile and Ca2+-cycling proteins in baboons?
Population
Baboons
Comparison
Thyroid hormone vs Control baboons and baseline state
Design
Preclinical
Authors
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Does not support thyroid hormone use to enhance LV performance in humans; leaves open mechanistic translation from primate models.
Does thyroid hormone alter left ventricular performance and the expression of contractile and Ca2+-cycling proteins in baboons?
Thyroid hormone enhances basal and frequency-dependent left ventricular performance in primates, mediated in part by transcriptional and posttranslational changes in Ca2+-cycling and contractile proteins.
Khoury et al. (1996) studied this question.
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