Why the study?
Does altered thyroid hormone level affect the expression and function of myocardial NCX and SERCA2 in developing rat hearts?
Population
Developing rat hearts (postnatal days 2 to 21)
Comparison
Hypothyroidism or Hyperthyroidism vs Euthyroid rats
Design
Preclinical
Follow-up
Postnatal days 2 to 21
Authors
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Thyroid hormone status alters NCX/SERCA2 in developing rat hearts; leaves open relevance to human neonatal thyroid-cardiac interactions.
Does altered thyroid hormone level affect the expression and function of myocardial NCX and SERCA2 in developing rat hearts?
Physiological thyroid hormone levels are essential for normal reciprocal changes in the expression and function of myocardial NCX and SERCA2 during postnatal development.
Cernohorský et al. (1998) studied this question.
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